chanelink logo
CHANELINK
English

New machine learning algorithm accurately decodes molecular optical 'fingerprints'

1493
2025-05-09 10:57:00
See translation

Recently, a research team from Rice University in the United States developed a new machine learning algorithm - Peak Sensitive Elastic Network Logistic Regression (PSE-LR). This algorithm is adept at interpreting the unique optical characteristics of molecules, materials, and disease biomarkers, which can help achieve faster and more accurate medical diagnosis and sample analysis. The relevant paper was published in the latest issue of the journal Nano.

The research team stated that the core breakthrough of this technology lies in teaching computers to recognize unique "fingerprints" generated by the interaction between molecules or materials and light. With the help of this technology, in the future, doctors may be able to capture early signals of Alzheimer's disease by simply shining light on a drop of liquid or tissue sample.

PSE-LR not only has the ability to distinguish autumn hair, but also has the interpretability of being open and honest. Unlike other "black box" machine learning models, it can generate clear "feature importance maps" that accurately highlight key spectral segments, making diagnostic results reliable, interpretable, traceable, and easy to verify.

Compared with other machine learning models, PSE-LR shows superior performance, especially in identifying subtle or overlapping spectral features. In addition, in the subsequent series of validation experiments, the performance of the algorithm was also commendable, including the successful detection of the trace presence of COVID-19 spike protein in the liquid, the accurate identification of neuroprotective components in mouse brain tissue, the effective differentiation of microscopic spectral differences in Alzheimer's disease samples, and the identification of the unique optical characteristics of two-dimensional semiconductor materials.

Source: Opticsky

Related Recommendations

  • Micro devices output powerful lasers at room temperature, reducing power consumption by 7 times

    Recently, researchers at the Rensselaer Polytechnic Institute in the United States have invented a miniature device thinner than human hair, which can help scientists explore the essence of light and matter and unravel the mysteries of the quantum field. The most important advantage of this technology is that it can work at room temperature without the need for complex infrastructure. The resea...

    2024-05-29
    See translation

  • Laser giant nLIGHT's preliminary performance forecast for the fourth quarter of 2024

    Recently, nLIGHT, a manufacturer of high-power semiconductors and fiber lasers, released its preliminary performance forecast for the fourth quarter of 2024.According to disclosed information, nLIGHT expects its revenue for the fourth quarter of 2024 to be between $46 million and $48 million, lower than the estimated range of $49 million to $54 million when it released its third quarter results on...

    01-16
    See translation

  • Relevant teams of the Chinese Academy of Sciences breakthrough the application difficulties of ultra compact gas laser system in special scenarios

    Recently, Liang Xu's team from the Laser Center of Anguang Institute, Chinese Academy of Sciences, Hefei Institute of Materia Medica, conducted research on corona discharge fluid control and its application in the gas laser system, proposed an electric field flow field coupling analysis model suitable for multi pin corona discharge scenarios, and revealed the flow velocity distribution characteris...

    2024-07-20
    See translation

  • Optimizing the phase focusing of laser accelerators

    With the help of on-chip accelerator technology, researchers at Stanford University are getting closer to manufacturing a miniature electron accelerator that can have various applications in industrial, medical, and physical research.Scientists have proven that silicon dielectric laser accelerators can now be used to accelerate and limit electrons, thereby producing concentrated high-energy electr...

    2024-02-29
    See translation

  • Application of Airborne Lidar Calibration Board in Various Fields

    With the rapid development of technology, airborne LiDAR technology has become one of the key technologies in modern surveying, remote sensing, navigation and other fields. As an important component of this technology, the airborne LiDAR calibration board plays a crucial role in ensuring the accuracy and stability of the radar system. This article will explore the application and importance of air...

    2024-04-08
    See translation