chanelink logo
CHANELINK
English

New machine learning algorithm accurately decodes molecular optical 'fingerprints'

1491
2025-05-09 10:57:00
See translation

Recently, a research team from Rice University in the United States developed a new machine learning algorithm - Peak Sensitive Elastic Network Logistic Regression (PSE-LR). This algorithm is adept at interpreting the unique optical characteristics of molecules, materials, and disease biomarkers, which can help achieve faster and more accurate medical diagnosis and sample analysis. The relevant paper was published in the latest issue of the journal Nano.

The research team stated that the core breakthrough of this technology lies in teaching computers to recognize unique "fingerprints" generated by the interaction between molecules or materials and light. With the help of this technology, in the future, doctors may be able to capture early signals of Alzheimer's disease by simply shining light on a drop of liquid or tissue sample.

PSE-LR not only has the ability to distinguish autumn hair, but also has the interpretability of being open and honest. Unlike other "black box" machine learning models, it can generate clear "feature importance maps" that accurately highlight key spectral segments, making diagnostic results reliable, interpretable, traceable, and easy to verify.

Compared with other machine learning models, PSE-LR shows superior performance, especially in identifying subtle or overlapping spectral features. In addition, in the subsequent series of validation experiments, the performance of the algorithm was also commendable, including the successful detection of the trace presence of COVID-19 spike protein in the liquid, the accurate identification of neuroprotective components in mouse brain tissue, the effective differentiation of microscopic spectral differences in Alzheimer's disease samples, and the identification of the unique optical characteristics of two-dimensional semiconductor materials.

Source: Opticsky

Related Recommendations

  • Composite two-dimensional materials for fiber lasers demonstrate the prospects of ultra fast optical applications

    The formation of dissipative solitons is influenced by various factors, such as spectral filtering effect and Kerr nonlinearity effect. This interaction leads to the possibility of mode locking on a large range of parameters, generating pulses with completely different types and evolution from conventional physical laws and optical properties, tolerating higher nonlinear effects, and effectively a...

    2023-09-21
    See translation

  • Germany's TRUMPF launches 50000 watt fiber laser

    TRUMPF will launch a new generation of efficient fiber lasers at the Munich Light Expo in Germany, which can meet the diverse welding needs of the entire industry, such as high-precision welding of electric vehicle batteries. Tom Rentschler, Product Manager of TRUMPF Fiber Laser, said, "The new generation TruFiber laser is the core engine of our production solutions. Through deep collaboration wit...

    06-20
    See translation

  • The research team of Xi 'an Jiaotong University and Northwestern Polytechnical University proposed a new technology of laser cutting water to provide a new idea for the application of "water"

    Water is a natural resource that human beings depend on for survival and is used in many fields. In recent years, the patterning and flow control of trace water have attracted wide attention in materials science, chemistry, biomedicine and other fields."Draw the knife to cut off the water more flow"? No, it's "Laser cut water pattern"! On September 1, the reporter learned that Xi 'an Jiaotong Univ...

    2023-09-05
    See translation

  • SPIE Optics and Photonics 2025: Kyle Myers from Puente elected as SPIE Chair

    The founder and principal of Puente Solutions Kyle J. Myers has been elected to serve as the 2026 Vice President of SPIE, the international society for optics and photonics. With her election, Myers joins the SPIE presidential chain. She will serve as president-elect in 2027, and as the Society’s president in 2028. Newly-elected: Myers, McNally, Rubinsztein-Dunlop, Wade, Medicus, and ErdmannTh...

    08-08
    See translation

  • Michigan State University uses laser pulses to impact gold nanoparticles for crystal growth

    To make crystals suitable for use as optoelectronic materials, the key is to precisely control the crystallization, but this control is difficult.Producing lead halide perovskites, promising components for next-generation solar cells and photodetectors, has proven particularly challenging, with slow growth rates and uncontrolled nucleation being common issues.A project at Michigan State University...

    10-16
    See translation